Monday, March 11, 2013

Easily affordable Web Hosting Systems For Your Blog. - Hellofour.com

For that top 10 website hosting and also critiques regarding This year, it can be just a little first to see whom comes to an end passionately in case your tournament had been organised currently, here is how we expect the last roundup could appear. 15: HostUpon ( blank ) HostUpon is just about the inexpensive hosting intentions of the market industry that has a $7.89 selling price per 30 days having an included 25 percent using a special discount code.

is without doubt one of the ideal makes within the on the net sector. If you need to avoid impotent brands, then special store is your most effective bet. Check it out at domain hosting providers register a website

Even though there are many hosting offered, finding a terrific coordinator for a great value is often complicated. Simply by realizing exactly what to look out for in a website coordinator, you'll be able to be sure you have become essentially the most reward for the investment.

Explore The top Different You are able to Discover that at private domain registration domain name registrar

Web hosting service Discounts lets you select in addition to take advantage the very best web hosting service program during this very competitive current market. Frequently fresh online businesses are developing in the realm of business online. It's your choice which enables someone to obtain the best operating as well as in premiums.

On the internet Buying and selling is simple, offers you true experience of buying and safe and sound and practical method of shopping for on domain name register best hosting

For more info in regards to domain registering stop by www.goreanlifestyle.com/blog/view/7619/ten-pathways-web-hosting-packages

Source: http://www.hellofour.com/blog/99628/easily-affordable-web-hosting-systems-for-your-blog/

Samantha Steele Dec 21 2012 doomsday Is The World Going To End Mayans camilla belle Robert Bork

CA-BUSINESS Summary

European shares dip on Italy worries, dollar firm

LONDON (Reuters) - European shares edged away from 4-1/2-year highs on Monday as weak economic data from China and worries about Italy undermined the optimism generated by last week's strong U.S. jobs numbers. The dollar was still rising on the payrolls data, touching a 3-1/2-year high against the yen and at a 3-month peak to the euro after the surprise employment growth boosted optimism over recovery in the world's largest economy.

Global economy: Shafts of sunshine try to pierce thick clouds

LONDON (Reuters) - Global economic news is improving here and there, but a batch of data due this week is unlikely to shake financial markets' conviction that major central banks are not about to take away the punch bowl. If anything, even more monetary easing could be in the pipeline.

Analysis: S&P paper trail may lead nowhere in government case

NEW YORK (Reuters) - In early 2007, as signs of distress began appearing in securities backed by residential mortgages, executives at Standard & Poor's began advising analysts responsible for rating mortgage bonds that they should put the phrase "privileged and confidential" on emails to one another. Analysts working for the McGraw Hill Cos division also were discouraged from doodling on notepads and official documents during meetings to discuss pending deals and existing ratings, several former S&P employees said.

Yum China recovery remains rocky even as online anger calms

SHANGHAI (Reuters) - Chinese consumers' anger at KFC over a food safety scare has abated as the number of negative posts about the fast food chain owned by Yum Brands Inc on the country's most popular microblogging platform fell by two-thirds. China's half a billion microbloggers posted 3 million overwhelmingly negative comments about KFC in the month that began on December 18, when state media started reporting on the scare over contaminated chicken, a Reuters review of data from the Twitter-like platform Weibo shows.

Cove Energy directors look to replicate success in Mozambique: FT

(Reuters) - Three key executives that were behind the creation and sale of Cove Energy Plc have reunited to raise funds for oil and gas exploration in waters off Mozambique, the Financial Times reported on Sunday. John Craven, Michael Blaha and Michael Nolan, now directors of Discover Exploration, are looking to raise about $50 million, the Financial Times reported.

Taiwan regulators, feet to the fire, talk tough on China-linked media deals

TAIPEI/HONG KONG (Reuters) - Taiwan regulators, under pressure from a public worried that Beijing may meddle in their media, have begun talking tough on TV and newspaper deals by Taiwanese businessmen with strong ties to the mainland. The island's media watchdog has proposed new anti-monopoly rules that could scuttle the $601 million sale of Next Media Ltd's Taiwan operations to a Taiwanese group including Want Want Holdings owner Tsai Eng-meng, who runs a multibillion dollar snacks-to-property empire in China.

IAG accepts mediator proposal in Iberia labor dispute

MADRID (Reuters) - IAG airline holding company has accepted a government-appointed mediator's compromise proposal to end a labor conflict over mass layoffs at Spanish flagship airline Iberia, the company said on Sunday. "The board has decided to accept the proposal," the company said in a statement. International Airlines Group, or IAG, is the holding company for Iberia and British Airways.

Analysis: Meat prices add to China's inflation, policy risks

BEIJING (Reuters) - Diners looking for some beef hotpot on a chilly evening in Beijing pay more per pound than their counterparts in Boston, a discrepancy that shows the challenges China faces in reviving growth as inflation pressures make an untimely return. China's consumer price index rose 3.2 percent in February from a year earlier, a 10-month high, official data released on Saturday showed. The pick up in inflation from just 2 percent in January was driven by a 6 percent increase in food costs.

Publishers oppose Amazon's bid to gain Web names: WSJ

NEW YORK (Reuters) - Two publishing industry groups, the Authors Guild and the Association of American Publishers, are opposing Amazon.com Inc's request to own new domain names, The Wall Street Journal reported. The organizations argue that allowing Amazon to have such domain addresses that end in suffixes such as ".book," ".author" and ".read" would be a threat to competition, the paper said.

China's ragtag shale army a long way from revolution

BEIJING (Reuters) - China's plans to unlock what could be the world's biggest shale gas reserves risk running further off track after 16 firms awarded exploration rights in the latest auction lacked one core skill - not one has drilled a gas well before. Beijing is hoping shale gas can transform the country in the same way as the U.S. boom, though to date there has been little commercial production and a target of producing 6.5 billion cubic meters of gas by 2015 in the world's biggest energy consumer looks out of reach, according to industry experts.

Source: http://news.yahoo.com/ca-business-summary-080432934--finance.html

Yunel Escobar Irish Daily Star Black Mesa matt ryan matt ryan att wireless Mother Jones

S. Korea, U.S. begin drills amid North's threats

SEOUL, South Korea (AP) ? North and South Korea staged dueling war games Monday as threatening rhetoric from the rivals rose to the highest level since North Korea rained artillery shells on a South Korean island in 2010.

Enraged over the South's joint military drills with the United States and recent U.N. sanctions, Pyongyang has piled threat on top of threat, including vows to launch a nuclear strike on the U.S. and to scrap the nearly 60-year-old armistice that ended the Korean War. Seoul has responded with tough talk of its own and has placed its troops on high alert.

North Korea's main newspaper, Rodong Sinmun, reported that the armistice was nullified Monday as Pyongyang had earlier announced. The North followed through on another promise Monday, shutting down a Red Cross hotline that the North and South used for general communication and to discuss aid shipments and separated families' reunions.

The 11-day military drills that started Monday involve 10,000 South Korean and about 3,000 American troops. Those coincide with two months of separate U.S.-South Korean field exercises that began March 1.

Also continuing are large-scale North Korean drills that Seoul says involve the army, navy and air force. The South Korean defense ministry said there have been no military activities it considers suspicious.

The North has threatened to nullify the armistice several times in times of tension with the outside world, and in 1996 the country sent hundreds of armed troops into a border village. The troops later withdrew.

Despite the heightened tension, there were signs of business as usual Monday.

The two Koreas continue to have at least two working channels of communication between their militaries and aviation authorities.

One of those hotlines was used Monday to give hundreds of South Koreans approval to enter North Korea to go to work. Their jobs are at the only remaining operational symbol of joint inter-Korean cooperation, the Kaesong industrial complex. It is operated in North Korea with South Korean money and knowhow and a mostly North Korean work force.

The North Korean rhetoric escalated as the U.N. Security Council last week approved a new round of sanctions over Pyongyang's latest nuclear weapons test Feb. 12.

Analysts said that much of the bellicosity is meant to shore up loyalty among citizens and the military for North Korea's young leader, Kim Jong Un.

"This is part of their brinksmanship," said Daniel Pinkston, a Seoul-based expert on North Korea with the International Crisis Group think tank. "It's an effort to signal their resolve, to show they are willing to take greater risks, with the expectation that everyone else caves in and gives them what they want."

Part of what North Korea wants is a formal peace treaty to end the Korean War, instead of the armistice that leaves the peninsula still technically in a state of war. It also wants security guarantees and other concessions, direct talks with Washington, recognition as a nuclear weapons state and the removal of 28,500 U.S. troops stationed in South Korea.

Pinkston said there is little chance of fighting breaking out while war games are being conducted, but he added that he expects North Korea to follow through with a somewhat mysterious promise to respond at a time and place of its own choosing.

North Korea was responsible for an artillery attack that killed four South Koreans in 2010. A South Korean-led international investigation found that North Korea torpedoed a South Korean warship that same year, killing 46 sailors. Pyongyang denies sinking the ship.

Among other threats in the past week, North Korea has warned Seoul of a nuclear war on the divided peninsula and said it was cancelling nonaggression pacts.

South Korean and U.S. officials have been closely monitoring Pyongyang's actions and parsing its recent rhetoric, which has been more warlike than usual.

One analyst said Kaesong's continued operations show that North Korea's cutting of the Red Cross communication channel was symbolic. More than 840 South Koreans were set to cross the border Monday to Kaesong, which provides a badly-needed flow of hard currency to a country where many face food shortages, according to Seoul's Unification Ministry.

"If South Koreans don't go to work at Kaesong, North Korea will suffer" financially, said analyst Hong Hyun-ik at the private Sejong Institute in South Korea. "If North Korea really intends to start a war with South Korea, it could have taken South Koreans at Kaesong hostage."

Under newly inaugurated President Park Geun-hye, South Korea's Defense Ministry, which often brushes off North Korean threats, has looked to send a message of strength in response to the latest comments from Pyongyang.

The ministry has warned that the North's government would "evaporate from the face of the Earth" if it ever used a nuclear weapon. The White House also said the U.S. is fully capable of defending itself against a North Korean ballistic attack.

On Monday, Park told a Cabinet Council meeting that South Korea should strongly respond to any provocation by North Korea. But she also said Seoul should move ahead with her campaign promise to build up trust with the North.

North Korea has said the U.S. mainland is within the range of its long-range missiles, and an army general told a Pyongyang rally last week that the military is ready to fire a long-range nuclear-armed missile to turn Washington into a "sea of fire."

While outside scientists are still trying to determine specifics, the North's rocket test in December and third atomic bomb test last month may have pushed the country a step closer to acquiring the ability to hit the U.S. with weapons of mass destruction. Analysts, however, say Pyongyang is still years away from acquiring the smaller, lighter nuclear warheads needed for a credible nuclear missile program.

But there are still worries about a smaller conflict, and analysts have said that more missile and nuclear tests are possible reactions from North Korea.

North Korea has a variety of missiles and other weapons capable of striking South Korea. Both the warship sinking and island shelling in 2010 occurred near a western sea boundary between the Koreas that North Korea fiercely disputes. It has been a recurring flashpoint between the rivals that has seen three other bloody naval skirmishes since 1999.

Last week, Kim Jong Un visited two islands just north of the sea boundary and ordered troops there to open fire immediately if a single enemy shell is fired on North Korean waters.

Kim was also quoted as saying his military is fully ready to fight an "all-out war" and that he will order a "just, great advance for national unification" if the enemy makes even a slight provocation, according to the North's official Korean Central News Agency.

Source: http://news.yahoo.com/skorea-us-begin-drills-nkorea-threatens-war-020933853.html

extenze tenacious d steve smith zou bisou bisou tim tebow press conference tebow press conference trina

London band Bastille storms to top of UK charts

LONDON (Reuters) - British rock band Bastille raced to the top of the charts with debut album "Bad Blood" this week, knocking off Brit award winner Emeli Sande from the top spot.

Sande, who received a major boost by appearing at the London Olympics opening and closing ceremonies last summer, came second with her album "Our Version Of Events", the Official Charts Company said on Sunday.

Welsh band Stereophonics' album "Graffiti On The Train" came third, followed by Bruno Mars, an American singer-songwriter and record producer, with his "Unorthodox Jukebox".

In singles, U.S. singer Justin Timberlake retained his top spot with "Mirrors", followed by Bruno Mars's "When I was your man" and Bastille's "Pompeii" at no. 2 and no.3, respectively.

(Writing by Maria Golovnina; Editing by Jason Webb)

Source: http://news.yahoo.com/london-band-bastille-storms-top-uk-charts-190405141.html

yeardley love nba all star reserves rock center christine christine will ferrell double fine adventure

Saturday, March 9, 2013

Z?calo Public Square :: Legal Journalist-Turned-Scholar Henry ...

Henry Weinstein

Henry Weinstein is a professor of law and literary journalism at UC Irvine; previously, he spent 30 years as a Los Angeles Times reporter, much of it covering legal affairs around the country. Before moderating a conversation with longtime New York Times Supreme Court reporter Linda Greenhouse, he revealed obsessions with mustard, T-shirts, and doing good in the world in the Z?calo green room.


Q:

What would you choose as your theme song?

A:

I?ve always been a great fan of a song called ?Wake Up Everybody? by Harold Melvin & the Blue Notes. It came out in the ?70s. It?s very melodic but has a strong political current to it?it talks about responding to social injustice. I?ll take that.


Q:

How do you pass the time when you?re stuck in traffic?

A:

I am a voracious listener to books on CD. At the moment I?m listening to Jeffrey Toobin?s new book on the Supreme Court, The Oath. I listen to lots of things?mysteries by George Pelecanos, long historical books like Robert Caro?s biography of LBJ. Books on CD have saved me from getting angry on the freeway many times.


Q:

You?ve reported from 36 states; if you didn?t live in California, which state would you choose?

A:

I think if I had to live in another place, I?d probably live in New York City or in New Orleans. I think New York is probably the most vibrant city in the country in terms of its vast array of cultural offerings. And I?m a big jazz fan. New York and New Orleans are the two cities in the country where you can hear great music any night of the week; I don?t know if that can be said of any other city, at least when it comes to jazz.


Q:

What?s your favorite secret Southern California spot?

A:

I?m not sure that I have a secret spot, to tell you the truth. I?m a big fan of Laguna Beach, where I first went when I was a small boy. My parents and some other families used to rent these cottages when you could go to Laguna Beach cheaply, when there was a real-life greeter in front of The Pottery Shack. I taught myself to body-surf there. And you can see the ocean from almost anywhere.


Q:

Where would we find you at 10:00 on a typical Sunday morning?

A:

You would almost always find me at the Hollywood Farmers Market. It?s about five minutes from my house. My wife and daughter and I have been going there for years. Typically we?ll get lots of fruits and vegetables. There?s also a stand I love that sells grilled chicken and bell peppers on a skewer. I?ll get an organic iced coffee and talk to Tony, the tangerine guy from Ojai. And I?ll eat raw oysters, too. I love the Farmers Market. I think it?s just a great place.


Q:

What do you feel conflicted about?

A:

Whether I?m doing enough good. During the 1992 presidential campaign, as you may recall, Bill Clinton took a very severe flaying in the media for ways people thought he manipulated to get out of the draft. It was very striking that in all those interviews, there was not one reporter who asked Clinton if he thought he had not done enough to stop the war. I look at people who stand up?I look at David Harris, who went to prison for two years. I was opposed to the war and marched in a lot of demonstrations, but I wasn?t that courageous. So I often ask myself, am I doing enough good, and am I being a good enough husband or parent?


Q:

If you had one more hour in the day, what would you do with it?

A:

More reading and more listening to music, probably.


Q:

What?s your favorite condiment?

A:

I am a total mustard freak. It?s a standing joke in my family that I normally have 10 to 12 mustards of various kinds. I will put mustard on almost anything. It will certainly make a piece of celery more appealing and liven up cottage cheese in the morning.


Q:

What do law and journalism students have in common?

A:

Curiosity. And in many instances?not all instances?a desire to do good. But I think intellectual curiosity and the ability to mentally unpeel onions.


Q:

What are you keeping in your closet that you should have thrown out already?

A:

My wife would tell you hundreds of old T-shirts, many from baseball stadiums I?ve been at, or from demonstrations in the ?60s. I have more T-shirts than mustards, and that?s saying something.



Source: http://www.zocalopublicsquare.org/2013/03/08/legal-journalist-turned-scholar-henry-weinstein/personalities/in-the-green-room/

terminator salvation terminator salvation deron williams jarhead montrose marshawn lynch earthquake bay area

Friday, March 8, 2013

Sony Xperia ZL Now Available in Australia for $700/?550 Outright

Sony Xperia Z is available for purchase in Australia for several days now at various retailers, but no carriers are offering the phone for the moment.

However, the Xperia ZL is a new entry on the Australian market, so those who prefer this one over the slightly more expensive Xperia Z can check it out now at major retailer Mobicity.

Sony Xperia ZL costs $700/?550 outright and is only available in black color. Mobicity also sells the Xperia Z for $750/?590, but this one is available in black, white and purple. Check it out here.

Android enthusiasts that cannot afford to pay the no-term price may want to wait until one of the three Australian major carriers will add the Xperia ZL to its portfolio.

For the time being, Vodafone Australia confirmed it would bring the Sony Xperia Z to its customers on March 13, but there?s no word on the Xperia ZL at the moment.

Although Xperia ZL does not offer a level of ruggedness included within the Sony Xperia Z device, it still comes with some features that the latter lacks. For example, the Xperia ZL features IR connectivity and a slightly better 2370 mAh Li-Ion battery.

Design is also a bit different as the Xperia ZL has a slimmer bezel than the Xperia Z. However, both smartphones ship with Android 4.1.2 Jelly Bean operating system until Sony decides it?s time to offer the promised Android 4.2 upgrade.

Hardware-wise, the two Xperia devices are similar and come packed with 1.5 GHz quad-core processors, Adreno 320 GPUs and 2GB of RAM.

The Xperia ZL embeds 16GB of internal memory that can be further expanded up to 64GB via microSD memory card.

Another selling point of the phone is the hyper-vibrant 5-inch Sony Mobile Bravia Engine 2 display that supports full HD (1080 x 1920 pixels) resolution.

Source: http://news.softpedia.com/news/Sony-Xperia-ZL-Now-Available-in-Australia-for-700-550-Outright-335245.shtml

barry sanders jimmie johnson juan pablo montoya crash chardon high school shooting mark martin cleveland news daytona race

Thursday, March 7, 2013

Scola reaches youth through Kerouac and McCarthy

(AP) ? To illustrate that life is a journey, one of the Italian cardinals touted as a favorite to be the next pope doesn't just turn to the Scriptures ? but also to Jack Kerouac and Cormac McCarthy.

Angelo Scola, the archbishop of Milan, is seen as Italy's best chance at reclaiming the papacy, following back-to-back popes from outside the country that had a lock on the job for centuries.

For one night last month, during the historic week that saw the shock resignation announcement of Pope Benedict XVI, Scola came across as a simple pastor leading a flock of 20-somethings in a discussion about faith. The powerful cardinal displayed not only an ease with youth but also a desire to make himself understood, a vital quality for a church that is bleeding membership. It was a sharp contrast with Benedict, who was almost painfully shy in public.

___

EDITOR'S NOTE: As the Roman Catholic Church prepares to elect a successor to Pope Benedict XVI, The Associated Press is profiling key cardinals seen as "papabili" ? contenders to the throne. In the secretive world of the Vatican, there is no way to know who is in the running, and history has yielded plenty of surprises. But these are the names that have come up time and again in speculation. Today: Angelo Scola.

___

Quoting from Kerouac's iconic Beat Generation novel "On the Road," Scola invited his audience of students to reflect on whether they "were going to get somewhere, or just going." And he cited McCarthy's post-apocalyptic father-son journey in "The Road," urging youths to consider the meaning of "destination" ? a key theme in McCarthy's work.

"The destination is a happy life, an accomplished life that doesn't end with death but with eternal life," the archbishop said.

Scola, 71, has commanded both the pulpits of Milan's Duomo as archbishop and Venice's St. Mark's Cathedral as patriarch, two extremely prestigious church positions that together gave the world five popes during the 20th century.

Scola was widely viewed as a papal contender when Benedict was elected eight years ago. His promotion to Milan, Italy's largest and most influential diocese, has been seen as a tipping point in making him a hot favorite for the papacy. But while Italy has the most cardinals ? 28 ? participating in the conclave, the Italian contingent is also said to be fractured among those inside the Roman Curia ? the Vatican's bureaucracy ? and those outside, where Scola enjoys more support.

Crucially, the Milan and Venice posts have allowed Scola to polish his pastoral credentials, adding human outreach to his already considerable intellectual achievements.

Vatican analyst John Thavis, who recently published "The Vatican Diaries" about the inner workings of the Holy See, recalls visiting Scola in Venice, where he generated "a great deal of enthusiasm" among parishioners, despite sometimes delivering a dense message.

"He is very dynamic, but he has a hard time speaking in simple language. I will be honest with you. There are times when Cardinal Scola can get rolling and you find yourself sort of in the clouds," Thavis said. "So it would be interesting if he is elected pope to see how he comes out and talks to the people."

Scola spent two decades after being ordained in 1970 studying in Europe's renowned Catholic universities and theological training grounds. His ties with Benedict, who named him to Milan, date from that academic period, when he began writing contributions for the Communio magazine co-founded by the future pope.

While Venice's cardinal, he founded a think tank ? Oasis ? which seeks dialogue with Islam, reflecting the lagoon city's historic position as a gateway between the East and the West. As Oasis has developed into a platform for dialogue, Scola has traveled frequently, making him one of the few Italian cardinals known abroad.

"Scola is one of the personalities that presents diverse talents and certain gifts that are to his advantage," said Sandro Magister, a Vatican analyst who closely monitors the institution's behind-the-scenes maneuvering. "He is certainly a solid theologian, formed along the same lines as (Benedict). ... This is already something to his advantage."

Scola is recognized as a conservative in the Church, rejecting the idea of women priests and denouncing consumerism. His association with the conservative Italian movement Communion and Liberation has raised eyebrows.

Scola was a theology student when he was invited to join the group, which blends political activism with faith-based fervor as it seeks to influence Italy's decision-making. Many prominent Italian politicians have been associated with the movement; in the 1970s Scola is said to have instructed former premier Silvio Berlusconi, then a real estate developer, in philosophy.

Scola more recently has sought to distance himself from the movement, especially as a number of officials linked to it have been swept into scandal. The Vatican's official biography of Scola says he stopped active participation in 1991, when John Paul II appointed him bishop of Grossetto in Tuscany.

The son of a truck driver and a homemaker, Scola is proud of his humble origins. He grew up in a small apartment in the town of Malgrate, on Lake Como; he is remembered by former neighbors and townspeople as having a terrific memory and showing an early dedication to religious activities. Both Scola and his younger brother were accomplished: Scola became a priest at 29, while his brother became the town's mayor. The brother, Pietro, died three decades ago in a traffic accident.

"He has maintained his relationships with many local citizens, with his friends, with his relatives," said Malgrate Mayor Giovanni Codega. "So much so that in this town he is called Don Angelo, instead of Cardinal or Patriarch of Venice."

That relaxed parish figure emerged during the recent hour-long gathering with some 1,000 Milan university students. Balancing a clipboard on his lap, he jotted notes as the youths poured out their dilemmas. He addressed students by name and weaved in ideas from previous responses and questions. He urged young people to be themselves and not to hide behind words that obscure meaning, acknowledging that sometimes terms in the Christian vocabulary are "a little cold."

The cardinal engaged all of the tools of technology to reach his youthful audience. The meeting was streamed on the diocesan web page and broadcast on local Catholic TV and radio stations. He fielded questions not only from participants but also those submitted via email and Twitter.

Yet Scola's own Twitter account disappeared this month in the days leading up to the cardinals meetings ahead of the conclave ? leaving one former follower to quip that he'd soon be using (at)Pontifex, the handle that had been used by Benedict during his papacy.

The university meeting was Scola's second encounter, in a period of just over a year, with students from the Milan diocese. Martino Frigerio, 22, said this time around, the cardinal appeared "looser."

Still grappling with Scola's proposals, which some characterized as "challenging," the students were loath to consider his chances at the papacy.

"We in Milan are possessive of him. We've had him such a short time," Frigerio said. "He has a way of communicating with young people in a way that is different."

____

Nicole Winfield, Patricia Thomas and Frances D'Emilio contributed to this report.

Associated Press

Source: http://hosted2.ap.org/APDEFAULT/cae69a7523db45408eeb2b3a98c0c9c5/Article_2013-03-06-Vatican-Cardinals-Scola/id-c2194968d2a74a968accfb75d98c4856

lil wayne Mockingbird Lane peyton manning sf giants gold rush gold rush windows 8

Portion of hippocampus found to play role in modulating anxiety

Mar. 6, 2013 ? Columbia University Medical Center (CUMC) researchers have found the first evidence that selective activation of the dentate gyrus, a portion of the hippocampus, can reduce anxiety without affecting learning. The findings suggest that therapies that target this brain region could be used to treat certain anxiety disorders, such as panic disorder and post-traumatic stress syndrome (PTSD), with minimal cognitive side effects. The study, conducted in mice, was published today in the online edition of the journal Neuron.

The dentate gyrus is known to play a key role in learning. Some evidence suggests that the structure also contributes to anxiety. "But until now no one has been able to figure out how the hippocampus could be involved in both processes," said senior author Rene Hen, PhD, professor of neuroscience and pharmacology (in psychiatry) at CUMC.

"It turns out that different parts of the dentate gyrus have somewhat different functions, with the dorsal portion largely dedicated to learning and the ventral portion dedicated to anxiety," said lead author Mazen A. Kheirbek, PhD, a postdoctoral fellow in neuroscience at CUMC.

To examine the role of the dentate gyrus in learning and anxiety, the investigators used a state-of-the-art technique called optogenetics, in which light-sensitive proteins, or opsins, are genetically inserted into neurons in the brains of mice. Neurons with these genes can then be selectively activated or silenced through the application of light (via a fiber-optic strand), allowing researchers to study the function of the cells in real time. Previously, the only way to study the dentate gyrus was to silence portions of it using such long-term manipulations as drugs or lesions, techniques that yielded conflicting results.

In the current study, opsins were inserted into dentate gyrus granule cells (the principal cells of the dentate gyrus). The researchers then activated or silenced the ventral or dorsal portions of the dentate gyrus for three minutes at a time, while the mice were subjected to two well-validated anxiety tests (the elevated plus maze and the open field test).

"Our main findings were that elevating cell activity in the dorsal dentate gyrus increased the animals' desire to explore their environment. But this also disrupted their ability to learn. Elevating activity in the ventral dentate gyrus lowered their anxiety, but had no effect on learning," said Dr. Kheirbek. The effects were completely reversible -- that is, when the stimulation was turned off, the animals returned to their previous anxiety levels.

"The therapeutic implication is that it may be possible to relieve anxiety in people with anxiety disorders by targeting the ventral dentate gyrus, perhaps with medications or deep-brain stimulation, without affecting learning," said Dr. Hen, who is also director of the Division of Integrative Neuroscience, the New York State Psychiatric Institute, and a member of The Kavli Institute for Brain Science. "Given the immediate behavioral impact of such manipulations, these strategies are likely to work faster than current treatments, such as serotonin reuptake inhibitors."

According to Dr. Hen, such an intervention would probably work best in people with panic disorder or PTSD. "There is evidence that people with these anxiety disorders tend to have a problem with pattern separation -- the ability to distinguish between similar experiences," he said. "In other words, they overgeneralize, perceiving minor threats to be the same as major ones, leading to a heightened state of anxiety. Such patients could conceivably benefit from therapies that fine-tune hippocampal activity."

Dr. Hen and his team are currently exploring strategies aimed at modulating the activity of the ventral dentate gyrus by stimulating neurogenesis in the ventral dentate gyrus. "Indeed the dentate gyrus is one of the few areas in the adult brain where neurons are continuously produced, a phenomenon termed adult hippocampal neurogenesis," added Dr. Hen.

The title of the paper is "Differential control of learning and anxiety along the dorso-ventral axis of the dentate gyrus." The other contributors are Liam J. Drew, Nesha S. Burghardt, Daniel O. Costantini, Lindsay Tannenholz, and Susanne E. Ahmari (CUMC); Hongkui Zeng (Allen Institute for Brain Science, Seattle, WA); and Andr? A. Fenton (New York University, New York, NY and SUNY Downstate Medical Center, Brooklyn, NY).

The study was supported by grants from the National Institutes of Health (1K01MH099371-01 and R37 MH068542), the National Alliance for Research on Schizophrenia and Depression, the Sackler Institute, the New York Stem Cell Initiative (NYSTEM C026430), and the Hope for Depression Research Foundation.

Share this story on Facebook, Twitter, and Google:

Other social bookmarking and sharing tools:


Story Source:

The above story is reprinted from materials provided by Columbia University Medical Center.

Note: Materials may be edited for content and length. For further information, please contact the source cited above.


Journal Reference:

  1. Mazen?A. Kheirbek, Liam?J. Drew, Nesha?S. Burghardt, Daniel?O. Costantini, Lindsay Tannenholz, Susanne?E. Ahmari, Hongkui Zeng, Andr??A. Fenton, Ren? Hen. Differential Control of Learning and Anxiety along the Dorsoventral Axis of the Dentate Gyrus. Neuron, 2013; 77 (5): 955 DOI: 10.1016/j.neuron.2012.12.038

Note: If no author is given, the source is cited instead.

Disclaimer: This article is not intended to provide medical advice, diagnosis or treatment. Views expressed here do not necessarily reflect those of ScienceDaily or its staff.

Source: http://feeds.sciencedaily.com/~r/sciencedaily/mind_brain/mental_health/~3/7zQ5NelYPqk/130306133802.htm

windows 8 Emanuel Steward college board nyc.gov SAT Notre Dame Football Schedule detroit tigers

Google Play Offers Over 5M eBooks And More Than 18M Songs, One Year After Its Rebranding

google-play-logoGoogle has just announced via its official blog that Google Play is officially one year old today. The actual marketplace itself is older than that, with the Android Market debuting in 2008, but it has been a year since Google changed the store's branding to reflect its broader purpose, which extends to media and use on platform besides its mobile OS. Google rehashed some of its previous milestones, but shed some new light on the size of two of its media categories: eBooks and music.

Source: http://feedproxy.google.com/~r/Techcrunch/~3/EhR8t-Mjodc/

san onofre paula deen birth control recall nick carter leslie carter aaron carter sister pfizer